Hello and welcome to this week’s edition of HealthBeat, Chiropractic OnLine Today’s Health, News and Informational Podcast.
In this week’s news: We’ll Be Looking At –
- Citrulline and Tight Junctions
- And Finally, a Story about Low Grade Inflammation and Aging
For HealthBeat …. This is Dr. Todd Eglow!
Welcome to HealthBeat Podcast #565 recorded September 23, 2016.
HealthBeat is Chiropractic OnLine Today’s radio program, providing current news and commentary about Chiropractic and Health.
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And Now for some news ….
Citrulline and Tight Junctions
Impairments of intestinal barrier function are discussed as risk factors for the development and progression of non-alcoholic fatty liver disease (NAFLD).
Studies suggest an association between arginine/citrulline homeostasis and the development of liver damages.
A recent study, published in the European Journal of Nutrition, found that the effect of an oral l-citrulline (Cit) supplement on the development of a Western-style diet (WSD)-induced NAFLD was determined in mice.
Data from the study’s conclusion suggest that the protective effects of supplementing oral l-citrulline on the development of non-alcoholic fatty liver disease in mice are associated with a decreased translocation of endotoxin into the portal vein.
As always, discuss all Nutritional Recommendations with your Qualified Healthcare Provider.
Surf to our Show Notes for links – http://link.springer.com/article/10.1007%2Fs00394-016-1287-9
Low Grade Inflammation and Aging
Despite a wealth of clinical data showing an association between inflammation and degenerative disorders in the elderly, the immune sensors that causally link systemic inflammation to aging remain unclear.
In a study published in the journal Cell Metabolism, the authors detail a mechanism by which the Nlrp3 inflammasome controls systemic low-grade age-related “sterile” inflammation in both periphery and brain independently of the inflammasome.
Ablation of Nlrp3 inflammasome protected mice from age-related increases in the innate immune activation, alterations in CNS transcriptome, and astrogliosis.
Consistent with the hypothesis that systemic low-grade inflammation promotes age-related degenerative changes, the deficient Nlrp3 inflammasome-mediated caspase-1 activity improved glycemic control and attenuated bone loss and thymic demise.
Notably, IL-1 mediated only Nlrp3 inflammasome-dependent improvement in cognitive function and motor performance in aged mice.
These studies reveal Nlrp3 inflammasome as an upstream target that controls age-related inflammation and offer an innovative therapeutic strategy to lower Nlrp3 activity to delay multiple age-related chronic diseases.
Surf to our Show Notes for Links – http://www.cell.com/cell-metabolism/abstract/S1550-4131(13)00379-3?_returnURL=http%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1550413113003793%3Fshowall%3Dtrue
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Finally, I leave you with the following quote:
“The Pessimist Sees Difficulty In Every Opportunity. The Optimist Sees The Opportunity In Every Difficulty.”
– Winston Churchill
For Chiropractic OnLine Today’s HealthBeat, This has been
Dr. Todd Eglow.