Hello and welcome to this week’s edition of HealthBeat, Chiropractic OnLine Today’s Health, News and Informational Podcast.
In this week’s news: We’ll Be Looking At –
- Glutamate receptors and pain
- And Finally, a story about Chronic Back Pain and Abnormal Brain Chemistry
For HealthBeat, wishing everyone a Safe, Healthy and Happy Holiday Season …. This is Dr. Todd Eglow!
Welcome to HealthBeat Podcast #576 recorded December 23, 2016.
HealthBeat is Chiropractic OnLine Today’s radio program, providing current news and commentary about Chiropractic and Health.
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And Now for some news ….
Glutamate receptors and pain
A 2006 study published in the journal Seminars in Cell & Developmental Biology, looked at the connection between the neurotransmitter Glutamate Receptors and Pain.
Pain is an important survival and protection mechanism for animals. However, chronic/persistent pain may be differentiated from normal physiological pain in that it confers no obvious advantage.
An accumulating body of pharmacological, electrophysiological, and behavioral evidence is emerging in support of the notion that glutamate receptors play a crucial role in pain pathways and that modulation of glutamate receptors may have potential for therapeutic utility in several categories of persistent pain, including neuropathic pain resulting from injury and/or disease of central (e.g., spinal cord injury) or peripheral nerves (e.g., diabetic neuropathy, radiculopathy) and inflammatory or joint-related pain (e.g., rheumatoid arthritis, osteoarthritis).
This review focuses on the role of glutamate receptors, including both ionotropic and metabotropic receptors in persistent pain states with particular emphasis on their expression patterns in nociceptive pathways and their potential as targets for pharmacological intervention strategies.
Surf to our Show Notes for Links – http://www.sciencedirect.com/science/article/pii/S1084952106001121
Chronic Back Pain and Abnormal Brain Chemistry
A 2000 study published in the journal Pain, looked at the relationship between Chronic Back Pain and Abnormal Brain Chemistry.
The neurobiology of chronic pain, including chronic back pain, is unknown.
Structural imaging studies of the spine cannot explain all cases of chronic back pain. Functional brain imaging studies indicate that the brain activation patterns are different between chronic pain patients and normal subjects, and the thalamus, and prefrontal and cingulate cortices are involved in some types of chronic pain.
Animal models of chronic pain suggest abnormal spinal cord chemistry.
The authors of the study used MRI to measure relative concentrations of N-acetyl aspartate, creatine, choline, glutamate, glutamine, gamma-aminobutyric acid, inositol, glucose and lactate in relation to the concentration of creatine.
The results of the study show that chronic back pain alters the human brain chemistry.
Reductions of N-acetyl aspartate and glucose were demonstrated in the dorsolateral prefrontal cortex. Cingulate, sensorimotor, and other brain regions showed no chemical concentration differences.
In chronic back pain, the interrelationship between chemicals within and across brain regions was abnormal, and there was a specific relationship between regional chemicals and perceptual measures of pain and anxiety.
These findings provide direct evidence of abnormal brain chemistry in chronic back pain, which may be useful in diagnosis and future development of more effective pharmacological treatments.
Surf to our Show Notes for links – https://www.ncbi.nlm.nih.gov/pubmed/11113288
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– Dr. Henry Link
For Chiropractic OnLine Today’s HealthBeat, This has been
Dr. Todd Eglow.